Benzimidazole for synthesis

Types of Benzimidazole for Synthesis

Benzimidazole for synthesis is important in producing several benzimidazole derivatives through the simple N-alkylation process of benzimidazole with the corresponding alkyl halides.

• 1-Methylbenzimidazole

  1-methylbenzimidazole is an important nitrogen heterocycle used in manufacturing antimicrobials and pharmaceuticals like pantoprazole and omeprazole. It is also applied in the field of biochemistry for tracking methyl groups in metabolic processes. 1-methylbenzimidazole is formed by methylating benimidazole using methyl iodide and potassium carbonate.

• 2-Methyl Benzimidazole

  2-methylbenzimidazole is relevant in synthesizing compounds like fungicides such as thiabendazole and drugs like albendazole. 2-methylbenzimidazole presents different properties than 1-methyl for the parent compound. 2-methylbenzimidazole is synthesized by reacting benzimidazole with methyl iodide in dimethylformamide (DMF) in the presence of potassium carbonate.

• 5-Bromobenzimidazole

  5-bromobenzimidazole is applied in further synthesis under the Suzuki cross-coupling reactions to introduce functional groups into the benimidazole ring. Pharmaceuticals like antifungal and anthelmintic compounds frequently use 5-bromobenzimidazole as a building block. Benzimidazole is formed by reacting 1H-benzimidazole with lithium bromide and 1-bromo-5-nitro-2-benzimidazole.

• 1H-benzimidazole-2-carboxylic acid

  The introduction of electronegative groups into the benzimidazole core is useful because they increase the electrophilicity of the nitrogen atom. This leads to the formation of new C–N bonds with the amino side chains of proteins. 1H-benzimidazole-2-carboxylic acid is synthesized by reacting 1H-benzimidazole with carbon dioxide under temperature and pressure.

• 2-Bromobenzimidazole

  2-bromobenzimidazole belongs to the halogenated benzimidazole derivatives. This variant increases biological activity and solubility in various solvents. The introduction of the bromine atom in the 2-position favors drug receptor interaction. 2-bromobenzimidazole is prepared through the radical bromination reaction of benzimidazole using N-bromosuccinimide (NBS).

Industrial Applications of Benzimidazole for Synthesis

Benzimidazole and its derivatives belong to the frequently used chemical compounds in various industries due to their biological activities.

• Pharmaceuticals and Medicine

  Benzimidazole is a key compound in synthesizing drugs with praziquantel, an important antiparasitic medication for schistosomiasis and other parasitic infections. Omeprazole, a medication used in treating gastric acid-related disorders, uses benzimidazole as a core structure. Albendazole, used to treat parasitic worm infections, contains a benzimidazole ring in its structure. Benzimidazole ring system is a characteristic feature of some antihypertensive medications, helping to regulate blood pressure.

• Agriculture

  Benzimidazole carbamate fungicides belong to widely used fungicides in agriculture. They act by inhibiting fungal cell division and are used to control diseases in crops. For instance, benomyl and carbendazim are important fungicides that control fungal infections on fruits, vegetables, and grains. They have broad-spectrum efficacy and are useful in protecting crops during storage and transportation.

• Chemicals and Material Science

  Benzimidazole derivatives are used as anticorrosion agents in manufacturing coatings and sealants. These compounds protect metals from rust and corrosion. Benzimidazole is used in polyamide and polyimide production. These polymers exhibit great thermal stability, chemical resistance, and mechanical strength. Benzimidazole and its derivatives are applied as curing agents for epoxy resins. The resins have great adhesive properties and are resistant to chemicals and heat.

• Textiles and Manufacturing

  Benzimidazole derivatives are used in developing high-performance fibers used in aerospace, automotive, and electrical applications. Polyamide fibers offer great tensile strength and thermal stability. The fibers are used in manufacturing garments with protective clothing against heat and flames.

• Cosmetics and Personal Care

  Benzimidazole compounds have antioxidant properties and are used in anti-aging creams and lotions. They help neutralize free radicals and minimize skin aging. Cationic benzimidazole derivatives are used in hair conditioners and shampoos. They help reduce static, detangle hair, and offer conditioning effects.

Product Specifications and Features of Benzimidazole for Synthesis

The product specifications of benzoic acid include the chemical structure, physical properties, synthesis methods, key features, and technical parameters important for various industrial applications.

Key Features

• Chemical Structure: Benzimidazoles consist of two fused rings, where one ring is a five-member nitrogen and carbon heterocyclic ring containing two nitrogen atoms at the 1 and 3 positions. The other ring is a six-member carbon aromatic ring bonded directly to the nitrogen of the first ring.
• Solubility: Most benzimidazole derivatives are slightly soluble in water due to their fused ring system. However, some alkylated or substituted derivatives can be more soluble in water and useful in pharmaceutical formulations.
• Molecular Weight: The molecular weight of benimidazole is 82.1 grams per mole. This can be different depending on the substituents and functional groups attached to the benzimidazole ring.
• Boiling Point: The boiling point of benzimidazole is 390°C. This can vary based on the substituents present on the benimidazole ring.
• Melting Point: 1H-benzimidazole melts at 112°C. This can change because of different substituents at various positions on the ring.
• Stability: Benzimidazole compounds are highly stable with resistance to degradation within a variety of chemical environments.
• Reactivity: They are generally unreactive. But substitution reactions at the nitrogen and carbon positions can make frebds easier.
• Biocompatibility: Many pharmaceutical applications of benzimidazoles are attributed to their biocompatibility characteristics.

How to Use

• Pharmaceutical Applications: Benzimidazole derivatives are used in synthesizing active pharmaceutical ingredients (APIs) such as albendazole, omeprazole, and nitazoxanide. These drugs are used to treat parasitic infections, gastrointestinal disorders, and viral infections, respectively. In the production process, benzimidazole is reacted with different reagents in multi-step synthesis to produce desired pharmaceutical compounds.
• Agricultural Chemicals: Benzimidazole derivatives are frequently used in producing fungicides and pesticides. Carbendazim and benomyl are broad-spectrum fungicides to control disease-causing fungi in a variety of crops. They are usually used in protecting fruits, vegetables, and grains during the growing and storage season.
• Polymer and Material Science: Functionalized benzimidazoles belong to important additives and monomers in manufacturing high-performance polymers. These polymers are useful in electrical insulation, fibers with great strength, and heat-resistant materials in industries like aerospace and automotive. Benzimidazole-based resins are widely used in adhesive production. These resins are valued for their high thermal stability and great adhesive properties.
• Textile Industry: Fibers created from benzimidazole-containing polymers are valued for their strength and resistance to heat and chemicals. They are used in protective clothing and components in several industrial applications.
• Cosmetic Industry: Antioxidant properties of benimidazole derivatives make them useful in anti-aging skin products and creams. Cationic benzimidazole derivatives are often used in conditioning agents within shampoos and hair care products.
• Laboratory and Research: Benzimidazole is commonly used in research to develop new pharmaceuticals and agrochemicals. Its versatile structure permits modification, leading to diverse derivatives for biological activity studies.

Maintenance and Repair

Maintenance, repair, and waste disposal of benzimidazole derivatives and related chemicals are crucial for safety and environmental protection. Here are some of the strategies for each.

• Benzimidazole Maintenance

  Benzimidazole-based products like polymers and resins require periodic inspection for strength deterioration and chemical degradation. Endeavor to check for discoloration, brittleness, or reduced tensile strength, which could signal degradation. Regular cleaning with non-abrasive methods will help save the products. Avoiding excessive temperatures and direct sunlight exposure will also boost the products’ durability. In case of damage, repair is usually possible through chemical treatments or reinforcements for various fiber products. In some cases, complete replacement will be required due to substantial degradation.

• Repurposed

  Repurposing is possible with benzimidazole-containing products whose useful life has expired but are still not hazardous. They can be modified or combined to make new materials with different properties. For instance, old treating fiber can be repurposed into insulation material for low-risk applications. Resins can be remixed with other polymers to produce composite materials for non-structural uses.

• Waste Disposal

  Proper waste disposal is crucial in preventing adverse environmental effects from toxic accumulation. No matter the situation, avoid throwing anything that contains hazardous chemical particles down the drain, into regular trash, or in unauthorized landfills. Laboratory-scale benzimidazole wastes should be collected in designated chemical waste containers. It should be managed according to local and international hazardous waste regulations. Benzimidazole derivatives with active pharmaceutical ingredients (APIs) require incineration under controlled conditions to limit the effect of toxic emissions. Agricultural chemicals should be disposed of following the agriculturally safe waste management hierarchy. This includes reducing the quantity, reusing appropriately rinsed containers, and disposing of residues in compliance with local regulatory authorities.

Quality Considerations & Tips for Buying Benzimidazole for Synthesis

The buyer’s guide and quality considerations of buying benzaldehyde chemical online include the following.

Quality Considerations

• Purity

  For benzimidazole to be effective in its various uses, it has to be pure. Always look for information regarding the chemical’s grade and purity. Pharmaceutical-grade benzimidazole has high purity than industrial-grade. In industrial-grade, there are small amounts of impurities which in pharmaceuticals may signal contamination and thus not good quality. The other contaminants to look out for are heavy metals, residual solvents, and unreacted starting materials. They all affect the chemical’s purity and affect its efficacy.

• Source

  The country of origin influences the quality of synthetic chemicals. Some countries have established themselves as leading producers of high-quality chemicals in adherence to strict regulatory standards. Others have bad quality products due to little adherence to international manufacturing standards. Get it from countries known for manufacturing high quality.

• COS and COA

  A Certificate of Analysis (COA) and Certificate of Suitability (COS) are crucial documents for additional quality assurance. The COS is a document that certifies a particular substance complies with the European Pharmacopoeia monograph for that substance. The COA is a document from the manufacturer that contains the test results of the product batch they are sending and gives a detailed analysis of the results. Both documents contain valuable information and assurance regarding quality and purity and can be requested from the supplier.

• Storage Conditions

  Improperly stored chemicals lose their effectiveness and can even become hazardous when their composition changes. When buying benzimidazole, ensure it is properly stored. Typically it is stored in a cool, dry place, away from direct sunlight and moisture exposure. It is usually contained in tightly sealed containers to reduce contamination and impurities gaining access. Improper storage exposes consumers to degraded chemicals of low purity, which could be dangerous.

Tips for Buying

• Reputation and Reviews

  Check the reputation of the supplier or manufacturer before placing an order. Confirm they have a proved track record of selling high-quality synthetic chemicals. Pharmaceutical and industrial chemicals require a consistent quality to be useful. When they get it from a reputable supplier, there is more certitude they will get it from a supplier with a reputable history of product quality.

• Sample Testing

  Samples are allowed. Before making wholesale purchases, buyer places a small order for testing. This ensures the product meets quality expectations and purity standards. It also allows for testing customer response to the product for those selling directly to consumers.

• Bulk Purchases

  Occasionally buy in bulk. This enables businesses to benefit from wholesale price cuts and discounts. Purchasing in bulk also ensures greater consistency in product quality and supply over an extended period.

• Compare Prices

  Take the time to compare prices from different suppliers. Only settle for the best. Keep in mind that quality is more important than the price. Though getting it at an affordable price is good, ensure it hasn’t lost efficacy. It has to be pure pharmaceutical-grade chemical for it to be effective.

Q&A

Q1. What is the role of benzimidazole in pharmaceuticals?

A1. Benzimidazole is useful in synthesizing drugs like omeprazole and albendazole. These drugs help in the treatment of acid-related disorders and parasitic infections, respectively. It is used combined with other chemicals to treat diseases.

Q2. Is Nitazoxanide an antiviral medication?

A2. Yes, Nitazoxanide is an broad-spectrum antiprotozoal and antiviral drug with great efficacy against a variety of viruses and parasites. Its versatility makes it useful in different disease treatments.

Q3. What are the important factors to consider when storing benzimidazole pharmaceuticals?

A3. Pharmaceuticals containing benzimidazole should be stored in a cool, dry place, away from direct light and moisture. It also should be in tightly closed containers to minimize contamination and exposure.

Q4. What are the environmental impacts of benzimidazole disposal?

A4. Benzimidazole leftover entries into the environment can negatively affect it. It can contaminate soil and water and influence microorganisms used in farming. It is essential to dispose of it according to hazardous waste regulations to mitigate its effect on non-target organisms.

Q5. Is there a role for benzimidazole in material science?

A5. Yes, benzimidazole is a valuable chemical in making high-performance polymers and fibers used in garments and industrial processes with fireproofing.